Inflammation, Temperature and Therapeutics
Dr. Hollander’s research group has examined the underlying mechanisms of a fever response and involvement of the immune-inflammatory system in autism via four approaches: 1. Oxytocin vs placebo in autism: (oxytocin not only has potent effects on social cognition and lower order repetitive behaviors but also has effects on obesity and wound healing; clinical response may be magnified in syndromal forms of autism– tuberous sclerosis and Prader Willi Syndrome), 2. Hyperthermia: children with autism are compared at temperatures of 102 degrees vs 98 degrees on clinical measures, biomarkers, and gene expression profiling, 3. LC/NE function as an outcome of maternal stress is examined by a milnacipran vs placebo trial of autism, 4. TSO (trichura suis ova; a helminth) vs placebo is examined in adult autism on clinical measures and biomarkers.
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