Jennifer Frankovich, MD, provides research updates on blood-brain barrier dysfunction in Pediatric Acute Neuropsychiatric Syndrome (PANS).

Playback of Dr. Mondal’s presentation and Dr. Hussein’s presentation will be available at a future date.

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The speakers:

Jennifer Frankovich: 

Dr. Frankovich is a Clinical Professor in the Department of Pediatrics, Division of Allergy, Immunology Rheumatology (AIR) at Stanford University/Lucile Packard Children’s Hospital (LPCH). Her clinical expertise is in systemic inflammatory and autoimmune diseases that co-occur with psychiatric symptoms. She completed her training in pediatrics, pediatric rheumatology, and clinical epidemiology at Stanford University/LPCH. She directs the Stanford Immune-Behavioral Health Program (2012- present) where she and her psychiatry/psychology collaborators have created a longitudinal clinical database and biorepository of patient and healthy control biospecimens. In addition to generating clinical data to better understand immune-behavioral health conditions, she is collaborating with basic science labs who aim to understand the immunological underpinnings of post-infectious neuropsychiatric conditions including PANS and related conditions.

Publishing soon:

Noor A. Hussein, PhD is a pharmacology scientist.
“My experience as a researcher has taught me to seek out new perspectives for exploration and discovery. As a dedicated biological and pharmacological researcher with over 7 years of experience with models of diseases such as cancer both in vitro and in vivo. During my masters and Ph.D. studies, I mastered lots of molecular biology techniques, including cell culture, cytotoxicity assays, western blot, quantitative PCR, immunofluorescence, flow cytometry. I utilized my skills to design experiments finding solutions to common problems in the biomedical field, especially cancer experimental and molecular therapeutics.”

Ayan Mondal, Ph.D. is a third-year post-doctoral research fellow in Prof Elizabeth Mellins’ laboratory at Dept of pediatrics, Stanford University. “I completed my graduation from University of Calcutta, India, in 2017. I have conducted 1.5 years of research on molecular medicine following graduation and joined as a post-doctoral researcher at the Arnold School of Public health, University of South Carolina, in the year 2019. During the training, I studied neuroimmune signaling mechanisms in the gut-liver-brain axes in mouse models of metabolic disorders and military-deployment-associated disorders. My studies elucidated the mechanism of neuroinflammation and blood-brain barrier (BBB) dysfunction mediated by specific proteins that are elevated in blood during these disease conditions. In my post-doctoral research with Prof Mellins, I am studying changes in BBB function in PANS. I am focusing on elucidating the mechanisms of action of novel modulators of BBB that are relevant to homeostatic maintenance of the BBB and other novel modulators that increase BBB permeability during flares of PANS. My proposed experimental strategies include transcriptomic and proteomic approaches in cell types of the CNS neurovascular unit.”

 

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